WELCOME TO MY HOME PAGE
Contact
Tieli (Tilly) Wang,
Tel: 310.243.3388
twang@csudh.edu
EDUCATION
PhD in Physiology and Biophysics, School of Medicine, State University of New York at Stony Brook
Ph.D. Candidate in Biochemistry, school of medicine, Case Western Reserve University
M.S. in Chemistry, Iowa State University
B.S. in Chemistry, Jilin University
AWARDS
Beckman Fellowship Award ($360,000), 2001-2004
Invited talk: College of Chemistry and College of Life Science, Jilin University, Changchun, China, 2005.
Invited talk: Beckman fellow symposium at Institute of California Technology, Pasadena, CA, 2004.
Invited talk: Research staff organization annual meeting 2004 at Lake arrowhead, CA 2004.
Invited talk: 92nd American Association for Cancer Research, New Orleans, LA, March 24-28, 2001.
Excellence in Research Award, SUNY Stony Brook, 1999.
RESEARCH EXPERIENCE
Assistant Professor, Department of Chemistry, California State University, Carson, California
6/2005 - present:
The role of peroxiredoxin in radiation resistant breast cancer cells. To understand the mechanism underlying radiation resistance and eventually find therapeutic methods to overcome this problem.
Beckman Fellow, Department of Medical Oncology, City of Hope National Medical Center,
Duarte, CA, 6/2001 - 6/2005:
Acquired radiation resistance breast cancer cell line (MCF+FIR30) is highly resistance to radiation and therefore suitable to be used as a model system to study the adaptive survival to chronic ionizing radiation. I have identified a peroxiredoxin protein that is significantly up regulated in radiation resistant breast cancer cells using comparative 2D proteomic analysis. I am further identifying the role of this protein in radiation resistant cancer cells.
Postdoctoral Associate, Department of Pharmacology, Fox Chase Cancer Center,
Philadelphia, PA, 9/1999 - 6/2001
Functional study of c-Jun and GST protein in cell signaling to drug resistance and stress response.
Doctoral Student, Department of Physiology and Biophysics, School of Medicine, SUNY at Stony Brook, Stony Brook, NY, 6/1995 - 9/1999
Mechanistic aspects of phospholipase C - beta isozymes in G-protein regulated signaling transduction pathway.
TEACHING EXPERIENCE
Teaching Assistant, Department of Physiology and Biophysics, SUNY at Stony Brook, Stony Brook, NY 1995-1999
oConducted twice-weekly review and discussion sessions
oAnswer questions and grade papers.
Student Consultant, Computer Lab at The Barry S Coller Learning Center, School of Medicine, SUNY at Stony Brook, Stony Brook, NY, 1996-1999
oAdvise medical school students on computer software application.
Teaching Assistant, Department of Chemistry, Iowa State University, Ames, IA, 1991-1995
oAttended lectures
oWrote test questions and graded papers
oConducted twice-weekly review and discussion sessions.
PUBLICATIONS:
1. Wang, T*., Tamae, D., Shiverly, J.E., Lee, T. and Li, J. J. (2005) The role of Prx II in radioresistant MCF-7 breast cancer cells. Cancer Research, Accepted.
2. Wang, T., Hu, YC.,Tamae, D., Ozeki, M., Gao, Q., Gius, D., and Li, JJ. (2005) Co-activation of NF B and Erk in protection cells from radiation toxicity. J Biol Chem., Vol. 280, Issue 13, 12593-12601.
3. Ozeki, M., Tamae, D., Hu, YC., Wang, T., and Li, J. J. ( 2004) Regulation of first intron of cycline B1 by NF B is affected by MnSOD expression. Anticancer Research, 24(5A):2657-63.
4. Wang, T., Guo, G., Wong, J., and Li, JJ. (2004) Expression of ErbB2 enhances radiation induced NF B activation. Oncogene. 23, 535-545.
5. Guo, G, Yan-Sanders, Y., Lyn-Cook, B. D, Wang, T., Tamae, D., and Li, JJ. (2003) NF B mediated manganese superoxide dismutase in radiation induced adaptive responses. Mol. Cell. Biol., 23, 2362-2378.
6. Wang, T., and Li, J. J. (2002) NF B activation and cell adaptive response. Int. J. Immunopharm., 2(11), 1509-1618.
7. Wang, T., Arifoglu,P., Ronai,Z., and Tew, KD. (2001) Probing the interaction between Glutathione S-Transferase P1-1 and c-Jun NH2 Terminal Kinase. J. Biol. Chem., 276(24): 20999-21003.
8. Ruscoe, JE., Rosario, LA., Wang, T., Gaté L., Arifoglu P., Wolf, CR, Henderson, CJ, Ronai, Z., and Tew, KD. (2001) Pharmacological or genetic manipulation of glutathione s-transferase p1-1 (GST ) influences cell proliferation pathways. J. Pharmacol. Exp. Ther. 298(1): 339-345.
9. Wang, T., Dowal L., El-Maghrabi, R., Rebecchi, M and Scarlata, S. (2000) The Pleckstrin homology domain of phospholipase C - ???links the binding of G to activation of the catalytic core. J. Biol. Chem., 275(11), 7466-7469.
10. Wang, T., Pentyala, S., Elliott, JT., Rebecchi, M. and Scarlata S. (1999) Selective Interaction of C2 Domain of Phospholipase C- 1, 2 with Active G q Subunits: An Alternative Function for C2 Signaling Modules. Proc. Natl. Acad. of Sci., USA., 96: 7843-7846.
11. Wang, T., Pentyala, S., Rebecchi M. and Scarlata, S. (1999) Differential Association of the Pleckstrin Homology Domains of Phospholipase C- 1, 2 and Phospholipase C- to Lipid Bilayers and the Subunits of G Proteins. Biochem., 38(5),1517-1524.
12.Mohan, T., Arumugam, S., Wang, T., Jacobson, R.A. and Verkade, J.G. (1996) Reactions of P(MeNCH2CH2)3N with primary, secondary and tertiary alkyl halides: Evidence for a solvent-enhanced dehydrohalogenation. Heteroatom-chemistry, 7, 455-460.
13. Pinkas J., Wang T., Jacobson R.A. and Verkade J.G. (1994) Azaaluminatranes exhibiting unusual coordination geometries for aluminum. Inorg. Chem., 33, 4202-4206.
14. Pinkas, J., Wang, T., Jacobson R.A. and Verkade, J.G. (1994) Group 13 Azatranes: Structure and Reactivity. Inorg. Chem., 33, 5244-5249.
15. White, CJ., Wang, T., Jacobson, RA., and Angelici, RJ. (1994) Synthesis, equilibrium binding, and Se-77 NMR-studies of eta(1)-selenophene (seln) complexes - [CPRU(CO)(PPH(3))(eta(1)(Se)-seln)]BF4. Organometallics ,13 (11), 4474-4480.
16. Bhaduri, D., Nelson, J.H., Wang T. and Jacobson, R.A. (1994) Synthesis and Reactions of Iron and Ruthenium Complexes of an Optically Pure Fused Cyclopentadienyl Ligand. Organometallics, 13, 2291-2298.
17. Wang, T., Yu, L. and Pang, W. (1990) Synthesis and characterization of a novel aluminophosphate with layer structure. J. Solid State Chem., 89, 392-396.
18. Wang, T., Yang, G., Feng, S., Shang, C., and Xu, R. (1989) Novel mixed octahedral framework: Ga2P2O8-C7. J. Chem. Soc. Chem. Commun., 849-851.
19. Zhu, Y., Wang, T., and Wang, Z. (1988) A MNDO program of DPS8 computer and its applications. Comput. Appl. Chem. 6, 56-59.
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